Epigenetic modification and regulation of HBV cccDNA
نویسندگان
چکیده
منابع مشابه
Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function.
HBV cccDNA, the template for transcription of all viral mRNAs, accumulates in the nucleus of infected cells as a stable episome organized into minichromosomes by histones and non-histone viral and cellular proteins. Using a cccDNA-specific chromatin immunoprecipitation (ChIP)-based quantitative assay, we have previously shown that transcription of the HBV minichromosome is regulated by epigenet...
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ژورنال
عنوان ژورنال: Chinese Science Bulletin
سال: 2019
ISSN: 0023-074X
DOI: 10.1360/tb-2019-0244